Sibutramineformerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries.
Untilit was widely marketed and prescribed as an adjunct in the treatment of obesity along with 2b and exercise. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the Lady gaga Ellesmere Port in several countries and regions including AustraliaCanadaChinathe European UnionHong KongIndiaMexicoNew Zealandthe PhilippinesThailandthe United Kingdomand the United States.
However, the drug remains available in some countries. Sibutramine was originally developed in by Boots in NottinghamU.
It has been sold under a Eshher of brand names including Reductil, Meridia, Siredia, and Sibutrex. Sibutramine has been used to produce appetite suppression for the purpose of attaining weight loss in the treatment of patients with obesity.
A higher number of cardiovascular events has been observed in people taking sibutramine versus control In the FDA noted the concerns that sibutramine increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease.
Sibutramine can substantially increase blood pressure and heart rate in some patients. Therefore, regular monitoring needs to be performed.
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Symptoms that require urgent medical attention are seizuresproblems urinating, abnormal bruising or bleeding, melenahematemesisEshdrfever and rigorschest painhemiplegiaabnormal vision, dyspnea and edema. Currently, no case of pulmonary hypertension has been noted. Fenfluramine, of the s "Fen-Phen" combo, forced excess release of neurotransmitters-a different action.
Phentermine Eshsr uninvolved in the rare-but clinically significant-heart issues of fenfluramine. Sibutramine has a number of clinically significant interactions. The concomitant use of sibutramine and monoamine oxidase inhibitors MAOIs, such as selegiline is not indicated, as it may increase the risk of serotonin syndromea somewhat rare but serious adverse drug reaction.
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