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However, the drug remains available in some countries. Sibutramine was originally developed in by Boots in NottinghamU.

It has been sold under a Eshher of brand names including Reductil, Meridia, Siredia, and Sibutrex. Sibutramine has been used to produce appetite suppression for the purpose of attaining weight loss in the treatment of patients with obesity.

A higher number of cardiovascular events has been observed in people taking sibutramine versus control In the FDA noted the concerns that sibutramine increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease.

Sibutramine can substantially increase blood pressure and heart rate in some patients. Therefore, regular monitoring needs to be performed.

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